CBD-infused topical gel works just like CBD cream in that it’s applied directly to the skin because it’s absorbed directly through the pores for effective, fast and long-lasting pain relief. What’s really nice here is that it can come in the form of a transdermal pen for quick and discreet application. The best way to apply CBD gel is to put it on your wrists, ankles, and neck. It’s perfect for the person that’s always on-the-go. CBD gel has the same health benefits as CBD massage cream without getting you high.