How CBD Works
Cannabidiol or CBD is the primary active component in industrial hemp, some of the benefits of CBD use include relief from pain, inflammation, depression, anxiety, smoking and stress. It does not have the "high" effect caused by THC. Industrial hemp derived CBD has less than 0.3% THC.
During the Reagan administration of the 1980’s, millions of dollars was spent on the War on Drugs research to prove marijuana was detrimental to the human brain. The studies focus was turned around and this led to the discovery of the endocannabinoid system.
The endocannabinoid system regulates the body and how it functions, this process is called homeostasis. If you get sick it sends immune cells to fight off infections and disease, heals cuts, reduces pain, inflammation stress, anxiety.
CBD acts as a regulator for the endocannabinoid system by indirectly stimulating cannabinoid receptors CB1 which is found in the central nervous system and CB2 receptors found in our cells which control our immune system. Instead of binding straight to the receptors as THC does, CBD elevates endocannabinoids
The findings of a team of Stony Brook University scientists, published online in the Journal of Biological Chemistry is significant because it helps explain how CBD works within the cells. CBD functions as an anandamide reuptake and breakdown inhibitor, thereby raising endocannabinoid levels in the brain’s synapses. Enhancing endocannabinoid tone via reuptake inhibition may be a key mechanism whereby CBD confers neuroprotective effects against seizures, as well as many other health benefits.
The paper, titled “Fatty Acid Binding Proteins are Intracellular Carriers for THC and CBD,” stem from the team’s research that spans five years and includes their discoveries that showed anandamide levels were raised in rodent brains using novel drugs targeted to FABPs. In 2013, they received a $3.8 million grant from the National Institute on Drug Abuse, part of the National Institutes of Health (NIH), to target endocannabinoid transporters to develop drugs for pain and inflammation.
CBD’s anti-inflammatory and anti-anxiety effects are in part attributable to its inhibition of adenosine reuptake. By delaying the reuptake of this neurotransmitter, CBD boosts adenosine levels in the brain, which regulates adenosine receptor activity. A1A and A2A adenosine receptors play significant roles in cardiovascular function, regulating myocardial oxygen consumption and coronary blood flow. These receptors have broad anti-inflammatory effects throughout the body.
The U.S. Food and Drug Administration’s approval in June 2018 a marijuana-derived medicine, followed by the DEA’s rescheduling in September of cannabinoid medicine that has FDA approval and no more than 0.1% THC, is opening up research opportunities.
The CBD world has grown from a tiny segment of the self-help wellness industry, into a major part of millions of people’s daily routine and further medical uses are on the horizon.